Immunomodulatory Effects of Non-Leukocyte-Depleted and Leukocyte-Depleted Autologous Blood

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Immunomodulatory Effects of Non-Leukocyte-Depleted and Leukocyte-Depleted Autologous Blood

Background: Based on several in vitro experiments, it has been suggested that autologous blood transfusion might lead to immunomodulation and that this effect might be prevented by leukocyte depletion. Clinical studies with surrogate endpoints showed conflicting results, whereas studies documenting clinically relevant outcomes were either too small or methodologically suboptimal to answer this ...

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Collection and storage of leukocyte depleted whole blood in autologous blood predeposit in elective surgery programs.

INTRODUCTION The aim of this investigation was to provide evidence that leukocyte depleted whole blood meets the requirements for transfusion of the European Council and thus may be an alternative to leukocyte and plasma depleted packed red blood cells in autologous blood predeposit for patients undergoing elective surgery programs. MATERIAL AND METHODS Standard units of 450mL blood were coll...

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Biochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion.

BACKGROUND To evaluate biochemical and cellular changes associated with the storage of leukocyte-depleted red blood cells (RBCs). METHODS We investigated 10 leukocyte-depleted RBC units, randomly chosen from volunteer donors. Every week an aliquot was collected for laboratorial evaluation, which included complete cell blood count, glucose-6-phosphate dehydrogenase (G6PD) activity, extracellul...

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Perioperative transfusion of leukocyte depleted blood products in gastric cancer patients negatively influences oncologic outcome

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Plasmapheresis With Return of Cryoglobulin - Depleted Autologous

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ژورنال

عنوان ژورنال: Transfusion Medicine and Hemotherapy

سال: 2006

ISSN: 1660-3796,1660-3818

DOI: 10.1159/000092257